University of Southern California · BiologySkin Development and Regeneration Unit
Cheng-Ming Chuong · Los Angeles, California
Research Focus
Dr. Cheng-Ming Chuong's lab at the University of Southern California focuses on understanding how skin develops and regenerates, particularly emphasizing the different characteristics of skin in various body regions. By studying chickens, which have distinct skin features, the lab aims to uncover the biological mechanisms that could lead to improved skin substitutes for patients with severe injuries. The research combines traditional techniques with advanced genomic technologies to explore how skin's structure and function are determined at both the genetic and epigenetic levels.
skin regenerationepigeneticsstem cellsmorphogensregional specificitytranscriptomicschromatinfeathersskin appendagestissue transplantation
Research Aims
5AIM 01Investigate how epigenetic profiles in the dermis influence skin region-specificity.
AIM 02Analyze the role of morphogens in the development of skin appendages.
AIM 03Study the genetic basis for the transformation of feathers to combs in chickens.
AIM 04Explore the chromatin accessibility in skin regions to uncover developmental pathways.
AIM 05Develop strategies for creating functional skin substitutes for regenerative medicine.
Skills the Lab Values
ATAC-seqChIP-seq3D genome organizationtissue transplantationtranscriptome analysismolecular cloningcell cultureanimal modelshistological techniques
Output against the department
Publications191top 33% of dept.345th of 1,033
this lab
most publishedleast published
Citations12ktop 31% of dept.325th of 1,033
this lab
most citedleast cited
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