Baylor College of Medicine · PhysiologyMuscle Function and Disorder Group
Susan L Hamilton · Houston, Texas
Research Focus
Susan L. Hamilton's lab at Baylor College of Medicine focuses on understanding how mutations in muscle proteins affect muscle function and increase susceptibility to conditions like malignant hyperthermia and heat stroke. The lab investigates the role of calcium leak from the sarcoplasmic reticulum, how this impacts muscle metabolism and endurance, and explores genetic and environmental factors that contribute to muscle disorders. Their research aims to identify new therapeutic strategies to improve muscle function in individuals with these genetic conditions.
muscle disorderscalcium signalingmalignant hyperthermiaheat strokesarcoplasmic reticulum
Research Aims
5AIM 01Investigate the role of calcium leak in muscle function.
AIM 02Identify how SPEG kinase affects muscle metabolism.
AIM 03Explore environmental and genetic factors contributing to heat sensitivity.
AIM 04Assess potential therapeutic interventions for congenital myopathies.
AIM 05Define the role of heat in metabolic changes in muscle.
Skills the Lab Values
mouse modelsmolecular biology techniquesprotein biochemistrygenetic analysisepigenetic profiling
Output against the department
Publications229top 26% of dept.74th of 286
this lab
most publishedleast published
Citations12ktop 27% of dept.78th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.