Thomas Jefferson University · Microbiology & ImmunologyLanguino Lab
Lucia R. Languino · Philadelphia, Pennsylvania
Research Focus
Dr. Lucia R. Languino's lab at Thomas Jefferson University focuses on understanding and targeting Neuroendocrine Prostate Cancer (NEPC), a rapidly advancing and treatment-resistant form of prostate cancer. The lab investigates how tumor cells adapt and metastasize in response to therapy, aiming to identify new therapeutic targets. Their work combines various projects that explore cellular communication, mitochondrial dysfunction, and the tumor microenvironment surrounding NEPC.
prostate cancerneuroendocrine cancermetastasistumor microenvironmentcell signalingmitochondrial dysfunctiontherapeutic vulnerabilitiesinflammationextracellular vesiclesbioinformatics
Research Aims
3AIM 01Elucidate the mechanisms of NEPC metastasis.
AIM 02Investigate how immune-inflammatory changes in the microenvironment affect NEPC progression.
AIM 03Identify novel therapeutic vulnerabilities resulting from NEPC cell plasticity.
Skills the Lab Values
cell culture3D cell modelingWestern blotRNA sequencingflow cytometrygenetically engineered mouse modelsbioinformaticsdata analysisin vivo imagingimmunohistochemistry
Output against the department
Publications368top 11% of dept.52nd of 486
this lab
most publishedleast published
Citations26ktop 13% of dept.62nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.