University of California-San Francisco · NeuroscienceThe Resilience Project
Kaitlin B Casaletto · San Francisco, California
Research Focus
Dr. Kaitlin B. Casaletto's lab focuses on understanding how biological sex influences dementia, particularly frontotemporal dementia (FTD). They investigate the roles of sex hormones and synaptic health in cognitive resilience, aiming to unlock new strategies for the prevention and treatment of Alzheimer's disease and related forms of dementia. This research hopes to address significant gaps in the current understanding of dementia's impact on different sexes.
frontotemporal dementiacognitive resiliencesex differencessynaptic biologyAlzheimer's diseaseneurodegenerationproteomicsphysical activitydisease progressionhormonal influences
Research Aims
4AIM 01Assess longitudinal sex hormone levels in plasma of individuals with FTD.
AIM 02Identify sex-specific proteomic signatures in cerebrospinal fluid and plasma related to FTD.
AIM 03Develop a reproductive health history measure for females at risk of FTD.
AIM 04Create models to predict FTD progression based on sex-specific biological factors.
Skills the Lab Values
longitudinal study designbiological sample processingproteomic analysisactigraphy data collectioncognitive assessmentstatistical modelingmachine learning techniquesdata visualizationneuroscience techniqueshuman subjects research
Output against the department
Publications223top 33% of dept.219th of 671
this lab
most publishedleast published
Citations6.2kbottom 43% of dept.384th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.