Vanderbilt University · PharmacologyThe Vision Proteomics Lab
Vsevolod V. Gurevich · Nashville, Tennessee
Research Focus
Dr. Vsevolod V. Gurevich's lab focuses on understanding the molecular interactions of a protein called arrestin-1 with rhodopsin, which is crucial for vision. Researchers in this lab study how different forms of rhodopsin affect arrestin-1 binding and explore ways to create modified versions of arrestin-1 that could help treat vision disorders related to defects in rhodopsin phosphorylation. The work involves a mix of molecular biology techniques and innovative labeling methods to discover new proteins that interact with arrestin-1.
rhodopsinarrestin-1visual disordersprotein interactionsmolecular mechanisms
Research Aims
4AIM 01Elucidate the binding mechanism of arrestin-1 to different rhodopsin states.
AIM 02Design arrestin-1 mutants with enhanced binding properties.
AIM 03Identify novel interaction partners of arrestin-1 in rod photoreceptors.
AIM 04Explore therapeutic applications of arrestin-1 mutants for visual disorders.
Skills the Lab Values
site-directed mutagenesismass spectrometryin vivo modelsbiotinylationelectroretinography
Output against the department
Publications449top 12% of dept.57th of 462
this lab
most publishedleast published
Citations24ktop 13% of dept.61st of 462
this lab
most citedleast cited
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