University of California-Berkeley · BiochemistryCate Translation Lab
Jamie H Cate · Berkeley, California
Research Focus
The Cate lab at UC Berkeley studies how protein synthesis, or translation, is regulated in humans. They focus on a special protein called eIF3 that controls how and when specific messenger RNAs are translated into proteins. This research is important because it can lead to new methods for treating diseases by better understanding translation control and developing new drugs targeting difficult-to-target proteins.
translation regulationprotein synthesiseIF3cellular immunotherapysmall molecule drugsribosome quality controlT cell development
Research Aims
5AIM 01Investigate how eIF3 regulates translation initiation and elongation in human cells.
AIM 02Explore the role of eIF3 in T cell development and activation.
AIM 03Determine how small molecules can regulate translation and target previously undruggable proteins.
AIM 04Map new ribosome quality control pathways involved in translation frameshifting.
AIM 05Examine the impact of cellular metabolites on translation regulation.
Skills the Lab Values
molecular cloningRNA extractionmass spectrometryfluorescence microscopycell culturebiochemical assaysstructural biology techniquesCRISPRpolymerase chain reaction (PCR)
Output against the department
Publications369top 15% of dept.59th of 402
this lab
most publishedleast published
Citations25ktop 15% of dept.61st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.