Johns Hopkins University · BiochemistryColler Lab
Jeffery Coller · Baltimore, Maryland
Research Focus
Professor Jeffery Coller's lab at Johns Hopkins University studies the role of codon optimality in determining the stability of messenger RNA (mRNA). By investigating how the rates at which ribosomes decode mRNA influence its degradation, the lab aims to uncover critical principles of gene regulation. Their research has implications for understanding cancer and viral infections, as these processes can disrupt normal cellular functions and exploit the mechanisms of gene expression.
mRNA stabilitycodon optimalitygene expressionribosome dynamicscellular regulation
Research Aims
5AIM 01Investigate how codon optimality affects mRNA stability.
AIM 02Determine the molecular events in ribosome translocation.
AIM 03Assess the influence of tRNA levels on mRNA degradation.
AIM 04Explore mRNA modifications that impact gene regulation.
AIM 05Examine the relationship between ribosome speed and mRNA turnover.
Skills the Lab Values
mRNA analysisribosome profilingcell culture techniquesmolecular cloningbiochemical assays
Output against the department
Publications114bottom 29% of dept.283rd of 402
this lab
most publishedleast published
Citations11ktop 44% of dept.177th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.