University of Michigan-Ann Arbor · GeneticsMueller Lab
Jacob L Mueller · Ann Arbor, Michigan
Research Focus
Dr. Jacob L. Mueller's lab at the University of Michigan focuses on understanding the competition between genes on sex chromosomes and how these interactions affect fertility. They study the roles of specific gene families that influence sperm success and investigate large palindromic DNA sequences in the genome to uncover their functions and evolutionary significance. By using advanced genetic techniques, the lab aims to provide insights into male infertility and the mechanisms of genetic inheritance.
gene competitionfertilitypalindromic DNAmale infertilityevolutionary biologysperm fertilizationgenomic analysis
Research Aims
4AIM 01Investigate how X and Y chromosome gene families influence sperm fertilization success.
AIM 02Characterize the role of large palindromic DNA sequences in selfish chromosome transmission.
AIM 03Assess the necessity of large palindromic arrays for male fertility.
AIM 04Model the molecular competition between specific gene products.
Skills the Lab Values
genome engineeringmassive parallel sequencinggene editingyeast three-hybridtransgenic mice modelingimmunoprecipitationcomparative genomic analysesmutation screeningdata analysis using Python
Output against the department
Publications43bottom 8% of dept.239th of 259
this lab
most publishedleast published
Citations2.7kbottom 15% of dept.221st of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.