University of California-San Francisco · BiologyImmune Response and Tissue Repair Lab
Ari B Molofsky · San Francisco, California
Research Focus
Dr. Ari B. Molofsky's lab at UCSF focuses on understanding the immune system's responses to allergens and brain injuries. The research primarily investigates how certain immune cells, called type 2 lymphocytes, function and localize within tissues during inflammation. The lab also explores the role of fibroblast cells in the brain and how they interact with the immune system to influence recovery from injury. The findings aim to inform future therapies for allergic diseases and neuroinflammatory conditions.
type 2 immunitylymphocytesfibroblastsbrain injuryimmune cellsallergyinflammationtissue repairneuroinflammation
Research Aims
4AIM 01Determine how type 2 lymphocytes migrate and localize during inflammation and its effects on organ function.
AIM 02Investigate the mechanisms behind fibroblast interactions with immune cells in the brain after injury.
AIM 03Characterize the transition of fibroblasts between functional states following CNS damage.
AIM 04Explore potential therapeutic strategies to modulate immune responses in allergic diseases.
Skills the Lab Values
cell cultureimmune cell isolationflow cytometrymouse modelsWestern blotRNA sequencingimmunofluorescencespatial transcriptomicsorgan transplantationparabiosis
Output against the department
Publications97bottom 34% of dept.679th of 1,033
this lab
most publishedleast published
Citations10ktop 36% of dept.368th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.