Washington University in St Louis · NeuroscienceThe NF1 Research Hub
David H Gutmann · Saint Louis, Missouri
Research Focus
Dr. David Gutmann's lab focuses on understanding neurofibromatosis type 1 (NF1) and its impact on brain tumors and neurodevelopmental problems in children. They aim to uncover the biological mechanisms behind NF1-related conditions to improve treatment strategies and patient outcomes. The lab utilizes integrative approaches, combining patient-derived cells, advanced genetic techniques, and mouse models to explore how different cell types interact in these diseases.
neurofibromatosislow-grade gliomaT cell regulationgene mutationneurodevelopmental deficitsprecision medicinecellular signalingimmune responsepersonalized therapy
Research Aims
5AIM 01Determine the cellular and molecular factors involved in NF1-related brain tumors.
AIM 02Investigate how immune cells, particularly T cells, influence tumor growth in NF1.
AIM 03Explore the variability in clinical outcomes associated with NF1.
AIM 04Define the interactions between neurons and immune cells in the context of glioma development.
AIM 05Develop novel therapeutic strategies based on understanding cellular circuits in NF1.
Skills the Lab Values
CRISPRmouse modelscell cultureflow cytometryRNA sequencinggenetic engineeringbioinformaticsimmunohistochemistrymulti-omic analysis
Output against the department
Publications970top 4% of dept.23rd of 671
this lab
most publishedleast published
Citations62ktop 4% of dept.30th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.