University of Texas Southwestern Medical Center · BiochemistrytRNA Modifications and Cancer Metabolism Lab
Joshua T Mendell · Dallas, Texas
Research Focus
Dr. Joshua T Mendell's lab focuses on understanding how specific modifications to transfer RNA (tRNA) impact the growth and spread of clear cell renal cell carcinoma (ccRCC), a type of kidney cancer. The lab investigates a newly discovered mechanism where altered tRNA modifications can change the way cancer cells metabolize energy, potentially leading to increased metastasis. By combining expertise in RNA biology and cancer research, the lab seeks to uncover new therapeutic targets for treatment.
tRNA modificationsrenal cell carcinomametabolismmetastasispost-transcriptional regulationDihydrouridineCCR4-NOT complexcryogenic electron microscopyRNA biologycancer biology
Research Aims
5AIM 01Investigate the role of dihydrouridine modifications in tRNA and their effects on mitochondrial metabolism.
AIM 02Assess how alterations in dihydrouridine synthase activity impact tRNA modification and cancer progression.
AIM 03Explore the molecular mechanisms by which tRNA modifications influence metastasis in clear cell renal cell carcinoma.
AIM 04Evaluate the potential therapeutic targets revealed by understanding tRNA-mediated decay pathways.
AIM 05Collaborate with experts to study how RNA modifications affect both cancer biology and normal physiology.
Skills the Lab Values
tRNA analysiscryogenic electron microscopycell cultureRNA sequencingmolecular cloningprotein analysiscellular metabolism assaysXenograft modelsbiochemical assaysstatistical analysis
Output against the department
Publications166bottom 48% of dept.210th of 402
this lab
most publishedleast published
Citations52ktop 4% of dept.17th of 402
this lab
most citedleast cited
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