University of Mississippi · BiochemistryThe Ocular Defense Lab
Mary E Marquart · University, Mississippi
Research Focus
Dr. Mary E. Marquart's lab focuses on developing a new treatment for bacterial endophthalmitis, a serious eye infection that can lead to blindness. The lab is researching a cocktail of antibodies that target the main bacterial culprits responsible for this condition. This innovative approach aims to protect the retina from damage caused by infection and inflammation, offering hope for improved eye treatments in conjunction with traditional antibiotics.
bacterial endophthalmitisantibody therapyocular inflammationeye infectionsretina protection
Research Aims
5AIM 01Develop a multivalent antibody cocktail to prevent eye damage from bacterial infection.
AIM 02Test the efficacy of antibodies against S. aureus and S. pneumoniae in protecting ocular tissues.
AIM 03Evaluate the combined effects of antibody treatment and antibiotics on retinal health.
AIM 04Investigate the specificity and affinity of the antibody cocktail in vitro.
AIM 05Translate findings into potential clinical treatments for bacterial endophthalmitis.
Skills the Lab Values
antibody purificationin vitro assaysrabbit modelsimmunoprecipitationAffinity chromatography
Output against the department
Publications115bottom 30% of dept.280th of 402
this lab
most publishedleast published
Citations1.9kbottom 7% of dept.374th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.