Duke University · Microbiology & ImmunologyThe Mucosal Immunity Lab
E. Ashley Moseman · Durham, North Carolina
Research Focus
Dr. E. Ashley Moseman's lab at Duke University focuses on understanding the immune responses in the upper respiratory tract, particularly how specific antibody-producing cells called plasma cells function to protect the olfactory mucosa. This research is crucial for improving vaccine strategies to better prevent infections like SARS-CoV-2 that target the respiratory system. By studying how these plasma cells establish and maintain residency in the tissue, the lab aims to enhance our understanding of local immunity against airborne pathogens.
plasma cellsolfactory mucosaupper respiratory infectionsSARS-CoV-2tissue resident immunity
Research Aims
4AIM 01Investigate the origin and longevity of plasma cells in the upper airway.
AIM 02Characterize the blood-olfactory barrier and its impact on immune response.
AIM 03Assess the role of tissue resident plasma cells in preventing viral infections.
AIM 04Examine how vaccine responses differ in terms of olfactory immune protection.
Skills the Lab Values
tissue cultureimmunohistochemistryantibody purificationRNA sequencingflow cytometry
Output against the department
Publications67bottom 19% of dept.389th of 486
this lab
most publishedleast published
Citations8.0ktop 45% of dept.218th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.