University of Texas Southwestern Medical Center · BiochemistryToxic Metals and RNA Modifications Lab
Yunsun Nam · Dallas, Texas
Research Focus
Dr. Yunsun Nam's lab at UT Southwestern Medical Center focuses on understanding how exposure to toxic heavy metals, like arsenic and cadmium, affects RNA modifications in cells. These modifications play a critical role in gene regulation, and the lab investigates how heavy metals disrupt these processes, potentially leading to harmful health effects like cancer. The research aims to reveal the molecular mechanisms behind these disruptions and their implications for cellular function and disease pathology.
epitranscriptomicsheavy metalsRNA modificationscarcinogenesismRNA methyltransferasemicroRNA biogenesischromatin remodelingtoxicologygene expression regulation
Research Aims
3AIM 01Investigate how heavy metals affect the enzymatic efficiency of mRNA methyltransferases.
AIM 02Analyze the activity of tRNA methyltransferases in the presence of heavy metals.
AIM 03Examine how heavy metals disrupt microRNA biogenesis and processing.
Skills the Lab Values
RNA sequencingcell cultureWestern blotmethylation assaysmicroRNA analysischromatin immunoprecipitationprotein purificationdata analysis with Rtransfection techniques
Output against the department
Publications47bottom 6% of dept.376th of 402
this lab
most publishedleast published
Citations5.8kbottom 33% of dept.269th of 402
this lab
most citedleast cited
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