University of North Carolina at Chapel Hill · PharmacologyCell Cycle Regulation Lab
Michael James Emanuele · Chapel Hill, North Carolina
Research Focus
Dr. Michael Emanuele's lab at the University of North Carolina Chapel Hill focuses on understanding how proteins regulate the cell cycle, particularly through a process called ubiquitination, which involves tagging proteins for degradation. His research examines the specific enzymes and proteins involved in this tagging process and their effects on cell growth and division. This work is crucial for uncovering how misregulation of these processes can lead to diseases like cancer.
cell cycleubiquitinationprotein degradationG2 phaseproteomicsenzyme kineticsE3 ligasesdeubiquitinasesproteostasiscancer research
Research Aims
5AIM 01Define the roles of E3 ligases in regulating protein dynamics during the cell cycle.
AIM 02Investigate the impact of deubiquitinases on cell cycle progression.
AIM 03Identify molecular changes that occur during the G2 phase in response to stress.
AIM 04Characterize the interactions between ubiquitin pathway enzymes and their substrates.
AIM 05Study the consequences of protein degradation on genome integrity and cellular decision-making.
Skills the Lab Values
cell culturebiochemical assaysproteomicscryoelectron microscopymolecular biology techniquesenzyme kinetics analysesWestern blottingcomputational modelingchromatin assaysfluorescence microscopy
Output against the department
Publications125bottom 36% of dept.296th of 462
this lab
most publishedleast published
Citations3.8kbottom 29% of dept.330th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.