University of Pennsylvania · BiologySpeck Lab
Nancy Speck · Philadelphia, Pennsylvania
Research Focus
Dr. Nancy Speck's lab focuses on understanding how a gene called RUNX1 influences inflammation in blood cells, particularly in patients who have mutations that can lead to blood cancers. Her research aims to uncover how these mutations affect immune responses, potentially contributing to cancer development. By studying both human patients and mouse models, the lab seeks to find ways to reduce harmful inflammation linked to these genetic changes.
RUNX1inflammationneutrophilsmyeloid progenitorscancerimmune responseepigenetics
Research Aims
5AIM 01Investigate how RUNX1 inhibits inflammatory signals in myeloid progenitors.
AIM 02Determine the effects of RUNX1 mutations on neutrophil cytokine production.
AIM 03Explore the role of type I interferon signaling in inflammatory responses.
AIM 04Analyze the epigenomic signatures in neutrophils of patients with RUNX1 mutations.
AIM 05Examine whether RUNX1 loss enhances innate immune training in mouse models.
Skills the Lab Values
PCRcell culturemouse modelsflow cytometryWestern blotRNA sequencingchromatin immunoprecipitationbioinformaticsimmunological assays
Output against the department
Publications250top 24% of dept.249th of 1,033
this lab
most publishedleast published
Citations20ktop 19% of dept.201st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.