University of California-San Diego · BiologySigurdson Lab
Christina Sigurdson · La Jolla, California
Research Focus
Christina Sigurdson's lab at UC San Diego focuses on understanding how prion diseases affect brain function and contribute to neurodegeneration. The research emphasizes the role of the ESCRT pathway in maintaining synaptic health and explores how prion proteins disrupt this process, leading to synaptic dysfunction and neuronal loss. By using advanced techniques like electrophysiology and microscopy, the lab aims to find new treatment strategies for fatal neurodegenerative disorders.
prion diseasessynaptic dysfunctionneuronal toxicityESCRT pathwayneuropathologyproteomicselectrophysiologyAlzheimer's diseaseneurodegeneration
Research Aims
5AIM 01Investigate how the ESCRT pathway contributes to synaptic health in prion disease.
AIM 02Determine the impact of Hrs expression on synaptic activity and structure.
AIM 03Assess how different prion conformers affect glutamatergic signaling.
AIM 04Examine the relationship between glutamate receptor activity and neurodegeneration.
AIM 05Compare findings from animal models to human prion-affected brain samples.
Skills the Lab Values
electrophysiologycorrelative light-electron microscopyproteomicscell culturelongitudinal studiesanimal modelsimmunoblottingneuron imaginggenetic manipulation
Output against the department
Publications120bottom 43% of dept.587th of 1,033
this lab
most publishedleast published
Citations14ktop 27% of dept.275th of 1,033
this lab
most citedleast cited
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