Iowa State University · EngineeringLiu Lab
Xiaoguang Margaret Liu · Ames, Iowa
Research Focus
Dr. Xiaoguang Margaret Liu's lab at Ohio State University focuses on developing innovative treatment strategies for triple-negative breast cancers (TNBCs), which are known for their aggressive nature and poor response to conventional therapies. By combining immunotherapy with novel drug delivery systems and gene therapies, the lab aims to improve cancer treatment efficacy and reduce recurrence rates. Key areas of research include antibody-drug conjugates and mitochondrial gene therapy, both designed to engage the immune system while directly targeting cancer cells.
triple-negative breast cancerimmunotherapyantibody-drug conjugatesgene therapysynthetic lethalitytumor microenvironment
Research Aims
3AIM 01Develop novel antibody-drug conjugates for treating triple-negative breast cancer.
AIM 02Evaluate the effectiveness of combined roles of chemotherapy and immunotherapy in TNBC models.
AIM 03Investigate the mechanisms of drug resistance in TNBC and assess new therapeutic strategies.
Skills the Lab Values
antibody-drug conjugate developmentflow cytometrycell culturemouse modelsbioluminescence imagingPCRimmunohistochemistryin vivo tumor modelstargeted therapy