University of California-San Francisco · PharmacologyStructural Dynamics Laboratory
James Solomon Fraser · San Francisco, California
Research Focus
Dr. James Solomon Fraser's lab at UCSF focuses on understanding the diverse structural forms that proteins can take, especially how these forms change in response to drugs or mutations. They develop advanced methods to visualize and manipulate these structures, aiming to improve drug design and create new treatments to fight antibiotic resistance. The lab combines experimental techniques in crystallography and cryo-electron microscopy with computational modeling to enhance our understanding of protein dynamics.
protein dynamicsmacromolecular conformationsdrug designantibiotic resistancestructural biologyensemble modelingligand discoveryprotein engineering
Research Aims
5AIM 01Investigate the effect of ligands on protein conformational states.
AIM 02Develop new experimental methods to observe dynamic macromolecular structures.
AIM 03Utilize computational modeling to enhance drug design processes.
AIM 04Explore the structural basis for new antibiotics to combat resistance.
AIM 05Establish open-access methods for data sharing and collaboration in research.
Skills the Lab Values
X-ray crystallographycryo-electron microscopyensemble modelingprotein mutational engineeringligand binding assaysdata analysistemperature perturbation techniquesopen research methodologies
Output against the department
Publications1bottom 1% of dept.459th of 462
this lab
most publishedleast published
Citations0bottom 1% of dept.460th of 462
this lab
most citedleast cited
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